San Francisco Giants at Chicago Cubs odds, picks and predictions (2024)

The San Francisco Giants (36-38) and Chicago Cubs (35-39) wrap up a 3-game set at Wrigley Field Wednesday. First pitch is scheduled for 2:20 p.m. ET. Let’s analyze FanDuel Sportsbook’s lines around the Giants vs. Cubs odds and make our expert MLB picks and predictions for the best bets.

Season series: Tied 1-1

After a 7-6 series-opening win, the Giants lost 5-2 as +105 underdogs Tuesday as the Under (9.5) hit. San Francisco has lost 3 of its last 5 games.

Cubs CF Cody Bellinger hit a go-ahead RBI single in the 8th inning, breaking a 2-2 tie. The win snapped a 2-game skid for Chicago, which cashed as a -114 favorite.

Giants at Cubs projected starters

TBD vs. RHP Kyle Hendricks

The Giants had not yet named a starter. RHP Spencer Howard (0-1, 4.02 ERA) started Friday after RHP Logan Webb‘s spot in the rotation and could be an option for the series finale. Howard has a 1.66 WHIP, 4.0 BB/9 and 5.7 K/9 in 2 starts and 2 relief appearances.

• Howard last start: Loss, 2 1/3 IP, 4 ER, 7 H, 4 BB, 1 K in Friday’s 8-6 home defeat vs. Los Angeles Angels
• Howard 2024 road stats: 0-0, 2.89 ERA (9 1/3 IP, 3 ER), 1.07 WHIP, 4.8 K/9 in 1 start and 1 relief appearance

Hendricks (0-4, 8.20 ERA) makes his 8th start and 13th appearance. He has a 1.71 WHIP, 3.0 BB/9 and 6.2 K/9 in 45 IP.

• Last outing: No-decision, 4 1/3 relief IP, 0 R, 2 H, 0 BB, 1 K in 3-0 home loss vs. St. Louis Cardinals Friday
• Last start: Loss, 4 2/3 IP, 7 ER (8 R), 11 H, 0 BB, 4 K in 9-3 home setback vs. Pittsburgh Pirates May 17
• 2024 home stats: 0-2, 7.36 ERA (22 IP, 18 ER), 1.77 WHIP, 7.4 K/9 in 3 starts and 3 relief appearances
• Career vs. Giants (regular season): 6-2, 2.36 ERA (76 1/3 IP, 20 ER), 0.94 WHIP, 7.2 K/9 in 12 starts, including 1-0 with 2.70 ERA (13 1/3 IP, 4 ER) in 2 starts last year

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Giants at Cubs odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 9:21 a.m. ET.

• Moneyline (ML): Giants +102 (bet $100 to win $102) | Cubs -120 (bet $120 to win $100)
• Run line (RL)/Against the spread (ATS): Giants -1.5 (+152) | Cubs +1.5 (-184)
• Over/Under (O/U): 11.5 (O: +104 | U: -128)

Giants at Cubs picks and predictions

Prediction

Giants 5, Cubs 4

Moneyline

TheGIANTS (+102) would be my lean with Hendricks starting for the Cubs. While the uncertainty at starting pitcher for San Francisco definitely gives me pause, in no scenario do I want to bet the Cubs with Hendricks on the mound unless I’m getting plus money.

LEAN GIANTS (+102).

Run line/Against the spread

It’s tough for me to feel confident in the run line either way without a starting pitcher confirmed for San Francisco. However, the Cubs have lost by multiple runs in Hendricks’ last 6 outings.

I would still PASS on the run line, though, until the Giants officially announce a starter. Bet the ML and/or total instead.

Over/Under

While Hendricks has allowed 4 ER or more in 6 of his 7 starts this season, this number seems a bit too high. The Cubs offense has been underperforming recently, and the Under is 10-1 in their last 11 games.

BET UNDER 11.5 (-128).

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